!Series_title	"Genome-wide chromosomal conformation elucidates regulatory relationships in human brain development and disease"
!Series_geo_accession	"GSE77565"
!Series_status	"Public on Oct 20 2016"
!Series_submission_date	"Feb 03 2016"
!Series_last_update_date	"Nov 30 2017"
!Series_pubmed_id	"27760116"
!Series_summary	"The demonstration that chromatin exhibits a complex 3 dimensional organization, whereby short and long distance physical interactions correspond to complex gene regulatory processes has opened a new window on understanding the functional organization of the human genome. Recently, chromatin remodeling has also been causally implicated in several neurodevelopmental disorders, including autism and schizophrenia. However, it remains unclear whether knowledge of chromosome organization in a tissue specific manner might inform our understanding of gene regulation in brain development or disease. Here we determined the genome-wide landscape of chromosome conformation during early human cortical development by performing Hi-C analysis in the mitotically active and post mitotic laminae of human fetal brain. We integrate Hi-C data with transcriptomic and epigenomic data and utilize chromosome contact information to delineate physical gene-gene regulatory interactions for non-coding regulatory elements. We show how these data permit large-scale functional annotation of non-coding variants identified in schizophrenia GWAS and of human specific enhancers. These data provide a rubric that illustrates the power of tissue-specific annotation of non-coding regulatory elements, as well as novel insights into the pathogenic mechanisms of neurodevelopmental disorders and the evolution of higher cognition."
!Series_overall_design	"Hi-C data of fetal cortical anlage from three individuals. SRA: SRP066745, BioProject ID: PRJNA304334, dbGaP: phs001190.v1.p1."
!Series_overall_design	""
!Series_overall_design	"*Raw reads are available through dbGaP (phs001190.v1.p1).*"
!Series_type	"Other"
!Series_contributor	"Daniel,H,Geschwind"
!Series_contributor	"Hyejung,,Won"
!Series_sample_id	"GSM2054564 GSM2054565 GSM2054566 GSM2054567 GSM2054568 GSM2054569 "
!Series_contact_name	"Hyejung,,Won"
!Series_contact_email	"wonhyejung87@gmail.com"
!Series_contact_phone	"3106000592"
!Series_contact_department	"Neurology"
!Series_contact_institute	"UCLA"
!Series_contact_address	"695 Charles E. Young Dr. South, Gonda 2309"
!Series_contact_city	"Los Angeles"
!Series_contact_state	"California"
!Series_contact_zip/postal_code	"90095"
!Series_contact_country	"USA"
!Series_supplementary_file	"ftp://ftp-trace.ncbi.nlm.nih.gov/sra/sra-instant/reads/ByStudy/sra/SRP/SRP066/SRP066745"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_CP_TAD.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Evolloci_interacting_region_enhctrl_ES_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Evolloci_interacting_region_enhctrl_FBD1_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Evolloci_interacting_region_enhctrl_FBD2_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Evolloci_interacting_region_enhctrl_FBD3_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Evolloci_interacting_region_enhctrl_FBD_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Evolloci_interacting_region_enhctrl_FBP1_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Evolloci_interacting_region_enhctrl_FBP2_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Evolloci_interacting_region_enhctrl_FBP3_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Evolloci_interacting_region_enhctrl_FBP_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Evolloci_interacting_region_enhctrl_IMR90_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_FBD_IC-heatmap-chr-10k.hdf5.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_FBD_IC-heatmap-chr-40k.hdf5.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_FBD_IC-heatmap-res-100k.hdf5.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_FBP_IC-heatmap-chr-10k.hdf5.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_FBP_IC-heatmap-chr-40k.hdf5.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_FBP_IC-heatmap-res-100k.hdf5.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_GZ_TAD.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Sczloci_interacting_region_ES_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Sczloci_interacting_region_FBD1_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Sczloci_interacting_region_FBD2_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Sczloci_interacting_region_FBD3_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Sczloci_interacting_region_FBD_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Sczloci_interacting_region_FBP1_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Sczloci_interacting_region_FBP2_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Sczloci_interacting_region_FBP3_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Sczloci_interacting_region_FBP_FDR.bed.gz"
!Series_supplementary_file	"ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE77nnn/GSE77565/suppl/GSE77565_Sczloci_interacting_region_IMR90_FDR.bed.gz"
!Series_platform_id	"GPL11154"
!Series_platform_taxid	"9606"
!Series_sample_taxid	"9606"
!Series_relation	"SRA: https://www.ncbi.nlm.nih.gov/sra?term=SRP066745"

!Sample_title	"CP, individual 1"	"CP, individual 2"	"CP, individual 3"	"GZ, individual 1"	"GZ, individual 2"	"GZ, individual 3"
!Sample_geo_accession	"GSM2054564"	"GSM2054565"	"GSM2054566"	"GSM2054567"	"GSM2054568"	"GSM2054569"
!Sample_status	"Public on Oct 20 2016"	"Public on Oct 20 2016"	"Public on Oct 20 2016"	"Public on Oct 20 2016"	"Public on Oct 20 2016"	"Public on Oct 20 2016"
!Sample_submission_date	"Feb 03 2016"	"Feb 03 2016"	"Feb 03 2016"	"Feb 03 2016"	"Feb 03 2016"	"Feb 03 2016"
!Sample_last_update_date	"Dec 07 2016"	"Dec 07 2016"	"Dec 07 2016"	"Dec 07 2016"	"Dec 07 2016"	"Dec 07 2016"
!Sample_type	"SRA"	"SRA"	"SRA"	"SRA"	"SRA"	"SRA"
!Sample_channel_count	"1"	"1"	"1"	"1"	"1"	"1"
!Sample_source_name_ch1	"Fetal brain"	"Fetal brain"	"Fetal brain"	"Fetal brain"	"Fetal brain"	"Fetal brain"
!Sample_organism_ch1	"Homo sapiens"	"Homo sapiens"	"Homo sapiens"	"Homo sapiens"	"Homo sapiens"	"Homo sapiens"
!Sample_characteristics_ch1	"developmental stage: Postconception week 18"	"developmental stage: Postconception week 18"	"developmental stage: Postconception week 17"	"developmental stage: Postconception week 18"	"developmental stage: Postconception week 18"	"developmental stage: Postconception week 17"
!Sample_characteristics_ch1	"tissue: Fetal cortex"	"tissue: Fetal cortex"	"tissue: Fetal cortex"	"tissue: Fetal cortex"	"tissue: Fetal cortex"	"tissue: Fetal cortex"
!Sample_characteristics_ch1	"layers: Cortical plate"	"layers: Cortical plate"	"layers: Cortical plate"	"layers: Germinal zone"	"layers: Germinal zone"	"layers: Germinal zone"
!Sample_molecule_ch1	"genomic DNA"	"genomic DNA"	"genomic DNA"	"genomic DNA"	"genomic DNA"	"genomic DNA"
!Sample_extract_protocol_ch1	"Fetal brains dissected into cortical plates (CP) and germinal zone (GZ)."	"Fetal brains dissected into cortical plates (CP) and germinal zone (GZ)."	"Fetal brains dissected into cortical plates (CP) and germinal zone (GZ)."	"Fetal brains dissected into cortical plates (CP) and germinal zone (GZ)."	"Fetal brains dissected into cortical plates (CP) and germinal zone (GZ)."	"Fetal brains dissected into cortical plates (CP) and germinal zone (GZ)."
!Sample_extract_protocol_ch1	"Tissue was fixed in 1% formaldehyde for 10 min. Cross-linked DNA was digested by restriction enzyme HindIII. Digested chromatin ends were filled and marked with biotin-14-dCTP. Resulting blunt-end fragments were ligated under dilute concentration to minimize random intermolecular ligations. DNA purified after crosslinking was reversed by proteinase K treatment. Biotins from unligated ends were removed by exonuclease activity of T4 DNA polymerase. DNA was sheared by sonication and 300-600bp fragments were selected. Biotin-tagged DNA, which is intermolecular ligation products, was pulled down with streptavidin beads (Invitrogen, 65001), and ligated with Illumina paired end adapters. Resulting Hi-C library was amplified by PCR and sequenced by Illumina 50bp paired-end sequencing."	"Tissue was fixed in 1% formaldehyde for 10 min. Cross-linked DNA was digested by restriction enzyme HindIII. Digested chromatin ends were filled and marked with biotin-14-dCTP. Resulting blunt-end fragments were ligated under dilute concentration to minimize random intermolecular ligations. DNA purified after crosslinking was reversed by proteinase K treatment. Biotins from unligated ends were removed by exonuclease activity of T4 DNA polymerase. DNA was sheared by sonication and 300-600bp fragments were selected. Biotin-tagged DNA, which is intermolecular ligation products, was pulled down with streptavidin beads (Invitrogen, 65001), and ligated with Illumina paired end adapters. Resulting Hi-C library was amplified by PCR and sequenced by Illumina 50bp paired-end sequencing."	"Tissue was fixed in 1% formaldehyde for 10 min. Cross-linked DNA was digested by restriction enzyme HindIII. Digested chromatin ends were filled and marked with biotin-14-dCTP. Resulting blunt-end fragments were ligated under dilute concentration to minimize random intermolecular ligations. DNA purified after crosslinking was reversed by proteinase K treatment. Biotins from unligated ends were removed by exonuclease activity of T4 DNA polymerase. DNA was sheared by sonication and 300-600bp fragments were selected. Biotin-tagged DNA, which is intermolecular ligation products, was pulled down with streptavidin beads (Invitrogen, 65001), and ligated with Illumina paired end adapters. Resulting Hi-C library was amplified by PCR and sequenced by Illumina 50bp paired-end sequencing."	"Tissue was fixed in 1% formaldehyde for 10 min. Cross-linked DNA was digested by restriction enzyme HindIII. Digested chromatin ends were filled and marked with biotin-14-dCTP. Resulting blunt-end fragments were ligated under dilute concentration to minimize random intermolecular ligations. DNA purified after crosslinking was reversed by proteinase K treatment. Biotins from unligated ends were removed by exonuclease activity of T4 DNA polymerase. DNA was sheared by sonication and 300-600bp fragments were selected. Biotin-tagged DNA, which is intermolecular ligation products, was pulled down with streptavidin beads (Invitrogen, 65001), and ligated with Illumina paired end adapters. Resulting Hi-C library was amplified by PCR and sequenced by Illumina 50bp paired-end sequencing."	"Tissue was fixed in 1% formaldehyde for 10 min. Cross-linked DNA was digested by restriction enzyme HindIII. Digested chromatin ends were filled and marked with biotin-14-dCTP. Resulting blunt-end fragments were ligated under dilute concentration to minimize random intermolecular ligations. DNA purified after crosslinking was reversed by proteinase K treatment. Biotins from unligated ends were removed by exonuclease activity of T4 DNA polymerase. DNA was sheared by sonication and 300-600bp fragments were selected. Biotin-tagged DNA, which is intermolecular ligation products, was pulled down with streptavidin beads (Invitrogen, 65001), and ligated with Illumina paired end adapters. Resulting Hi-C library was amplified by PCR and sequenced by Illumina 50bp paired-end sequencing."	"Tissue was fixed in 1% formaldehyde for 10 min. Cross-linked DNA was digested by restriction enzyme HindIII. Digested chromatin ends were filled and marked with biotin-14-dCTP. Resulting blunt-end fragments were ligated under dilute concentration to minimize random intermolecular ligations. DNA purified after crosslinking was reversed by proteinase K treatment. Biotins from unligated ends were removed by exonuclease activity of T4 DNA polymerase. DNA was sheared by sonication and 300-600bp fragments were selected. Biotin-tagged DNA, which is intermolecular ligation products, was pulled down with streptavidin beads (Invitrogen, 65001), and ligated with Illumina paired end adapters. Resulting Hi-C library was amplified by PCR and sequenced by Illumina 50bp paired-end sequencing."
!Sample_taxid_ch1	"9606"	"9606"	"9606"	"9606"	"9606"	"9606"
!Sample_description	"processed data file: FBD_IC-heatmap-chr-10k.hdf5"	"processed data file: FBD_IC-heatmap-chr-10k.hdf5"	"processed data file: FBD_IC-heatmap-chr-10k.hdf5"	"processed data file: FBP_IC-heatmap-chr-10k.hdf5"	"processed data file: FBP_IC-heatmap-chr-10k.hdf5"	"processed data file: FBP_IC-heatmap-chr-10k.hdf5"
!Sample_description	"processed data file: FBD_IC-heatmap-chr-40k.hdf5"	"processed data file: FBD_IC-heatmap-chr-40k.hdf5"	"processed data file: FBD_IC-heatmap-chr-40k.hdf5"	"processed data file: FBP_IC-heatmap-chr-40k.hdf5"	"processed data file: FBP_IC-heatmap-chr-40k.hdf5"	"processed data file: FBP_IC-heatmap-chr-40k.hdf5"
!Sample_description	"processed data file: FBD_IC-heatmap-res-100k.hdf5"	"processed data file: FBD_IC-heatmap-res-100k.hdf5"	"processed data file: FBD_IC-heatmap-res-100k.hdf5"	"processed data file: FBP_IC-heatmap-res-100k.hdf5"	"processed data file: FBP_IC-heatmap-res-100k.hdf5"	"processed data file: FBP_IC-heatmap-res-100k.hdf5"
!Sample_description	"processed data file: Sczloci_interacting_region_FBD_FDR.bed"	"processed data file: Sczloci_interacting_region_FBD_FDR.bed"	"processed data file: Sczloci_interacting_region_FBD_FDR.bed"	"processed data file: Sczloci_interacting_region_FBP_FDR.bed"	"processed data file: Sczloci_interacting_region_FBP_FDR.bed"	"processed data file: Sczloci_interacting_region_FBP_FDR.bed"
!Sample_description	"processed data file: Evolloci_interacting_region_enhctrl_FBD_FDR.bed"	"processed data file: Evolloci_interacting_region_enhctrl_FBD_FDR.bed"	"processed data file: Evolloci_interacting_region_enhctrl_FBD_FDR.bed"	"processed data file: Evolloci_interacting_region_enhctrl_FBP_FDR.bed"	"processed data file: Evolloci_interacting_region_enhctrl_FBP_FDR.bed"	"processed data file: Evolloci_interacting_region_enhctrl_FBP_FDR.bed"
!Sample_data_processing	"Library strategy: Hi-C"	"Library strategy: Hi-C"	"Library strategy: Hi-C"	"Library strategy: Hi-C"	"Library strategy: Hi-C"	"Library strategy: Hi-C"
!Sample_data_processing	"alignment: bowtie2 (--score-min -L 0.6,0.2--very-sensitive)"	"alignment: bowtie2 (--score-min -L 0.6,0.2--very-sensitive)"	"alignment: bowtie2 (--score-min -L 0.6,0.2--very-sensitive)"	"alignment: bowtie2 (--score-min -L 0.6,0.2--very-sensitive)"	"alignment: bowtie2 (--score-min -L 0.6,0.2--very-sensitive)"	"alignment: bowtie2 (--score-min -L 0.6,0.2--very-sensitive)"
!Sample_data_processing	"filtering and bias correction: hiclib"	"filtering and bias correction: hiclib"	"filtering and bias correction: hiclib"	"filtering and bias correction: hiclib"	"filtering and bias correction: hiclib"	"filtering and bias correction: hiclib"
!Sample_data_processing	"normalization: hiclib"	"normalization: hiclib"	"normalization: hiclib"	"normalization: hiclib"	"normalization: hiclib"	"normalization: hiclib"
!Sample_data_processing	"Genome_build: hg19"	"Genome_build: hg19"	"Genome_build: hg19"	"Genome_build: hg19"	"Genome_build: hg19"	"Genome_build: hg19"
!Sample_data_processing	"Supplementary_files_format_and_content: *hdf5 files contain a normalized chromatin contact matrix at different resolutions, included in file name (10kb, 40kb, 100kb); Sczloci*.bed files contain schizophrenia GWAS loci interacting regions, and Evolloci*.bed files contain Human-gained enhancer interacting regions; CP_TAD.bed file contains TAD coordinates in bed file format for CP (cortical plate); GZ_TAD.bed contains TAD coordinates in bed file format for GZ (germinal zone)."	"Supplementary_files_format_and_content: *hdf5 files contain a normalized chromatin contact matrix at different resolutions, included in file name (10kb, 40kb, 100kb); Sczloci*.bed files contain schizophrenia GWAS loci interacting regions, and Evolloci*.bed files contain Human-gained enhancer interacting regions; CP_TAD.bed file contains TAD coordinates in bed file format for CP (cortical plate); GZ_TAD.bed contains TAD coordinates in bed file format for GZ (germinal zone)."	"Supplementary_files_format_and_content: *hdf5 files contain a normalized chromatin contact matrix at different resolutions, included in file name (10kb, 40kb, 100kb); Sczloci*.bed files contain schizophrenia GWAS loci interacting regions, and Evolloci*.bed files contain Human-gained enhancer interacting regions; CP_TAD.bed file contains TAD coordinates in bed file format for CP (cortical plate); GZ_TAD.bed contains TAD coordinates in bed file format for GZ (germinal zone)."	"Supplementary_files_format_and_content: *hdf5 files contain a normalized chromatin contact matrix at different resolutions, included in file name (10kb, 40kb, 100kb); Sczloci*.bed files contain schizophrenia GWAS loci interacting regions, and Evolloci*.bed files contain Human-gained enhancer interacting regions; CP_TAD.bed file contains TAD coordinates in bed file format for CP (cortical plate); GZ_TAD.bed contains TAD coordinates in bed file format for GZ (germinal zone)."	"Supplementary_files_format_and_content: *hdf5 files contain a normalized chromatin contact matrix at different resolutions, included in file name (10kb, 40kb, 100kb); Sczloci*.bed files contain schizophrenia GWAS loci interacting regions, and Evolloci*.bed files contain Human-gained enhancer interacting regions; CP_TAD.bed file contains TAD coordinates in bed file format for CP (cortical plate); GZ_TAD.bed contains TAD coordinates in bed file format for GZ (germinal zone)."	"Supplementary_files_format_and_content: *hdf5 files contain a normalized chromatin contact matrix at different resolutions, included in file name (10kb, 40kb, 100kb); Sczloci*.bed files contain schizophrenia GWAS loci interacting regions, and Evolloci*.bed files contain Human-gained enhancer interacting regions; CP_TAD.bed file contains TAD coordinates in bed file format for CP (cortical plate); GZ_TAD.bed contains TAD coordinates in bed file format for GZ (germinal zone)."
!Sample_platform_id	"GPL11154"	"GPL11154"	"GPL11154"	"GPL11154"	"GPL11154"	"GPL11154"
!Sample_contact_name	"Hyejung,,Won"	"Hyejung,,Won"	"Hyejung,,Won"	"Hyejung,,Won"	"Hyejung,,Won"	"Hyejung,,Won"
!Sample_contact_email	"wonhyejung87@gmail.com"	"wonhyejung87@gmail.com"	"wonhyejung87@gmail.com"	"wonhyejung87@gmail.com"	"wonhyejung87@gmail.com"	"wonhyejung87@gmail.com"
!Sample_contact_phone	"3106000592"	"3106000592"	"3106000592"	"3106000592"	"3106000592"	"3106000592"
!Sample_contact_department	"Neurology"	"Neurology"	"Neurology"	"Neurology"	"Neurology"	"Neurology"
!Sample_contact_institute	"UCLA"	"UCLA"	"UCLA"	"UCLA"	"UCLA"	"UCLA"
!Sample_contact_address	"695 Charles E. Young Dr. South, Gonda 2309"	"695 Charles E. Young Dr. South, Gonda 2309"	"695 Charles E. Young Dr. South, Gonda 2309"	"695 Charles E. Young Dr. South, Gonda 2309"	"695 Charles E. Young Dr. South, Gonda 2309"	"695 Charles E. Young Dr. South, Gonda 2309"
!Sample_contact_city	"Los Angeles"	"Los Angeles"	"Los Angeles"	"Los Angeles"	"Los Angeles"	"Los Angeles"
!Sample_contact_state	"California"	"California"	"California"	"California"	"California"	"California"
!Sample_contact_zip/postal_code	"90095"	"90095"	"90095"	"90095"	"90095"	"90095"
!Sample_contact_country	"USA"	"USA"	"USA"	"USA"	"USA"	"USA"
!Sample_data_row_count	"0"	"0"	"0"	"0"	"0"	"0"
!Sample_instrument_model	"Illumina HiSeq 2000"	"Illumina HiSeq 2000"	"Illumina HiSeq 2000"	"Illumina HiSeq 2000"	"Illumina HiSeq 2000"	"Illumina HiSeq 2000"
!Sample_library_selection	"other"	"other"	"other"	"other"	"other"	"other"
!Sample_library_source	"genomic"	"genomic"	"genomic"	"genomic"	"genomic"	"genomic"
!Sample_library_strategy	"OTHER"	"OTHER"	"OTHER"	"OTHER"	"OTHER"	"OTHER"
!Sample_relation	"BioSample: https://www.ncbi.nlm.nih.gov/biosample/SAMN04309154"	"BioSample: https://www.ncbi.nlm.nih.gov/biosample/SAMN04309155"	"BioSample: https://www.ncbi.nlm.nih.gov/biosample/SAMN04309156"	"BioSample: https://www.ncbi.nlm.nih.gov/biosample/SAMN04316928"	"BioSample: https://www.ncbi.nlm.nih.gov/biosample/SAMN04316929"	"BioSample: https://www.ncbi.nlm.nih.gov/biosample/SAMN04316930"
!Sample_relation	"SRA: https://www.ncbi.nlm.nih.gov/sra?term=SRX1462311"	"SRA: https://www.ncbi.nlm.nih.gov/sra?term=SRX1462312"	"SRA: https://www.ncbi.nlm.nih.gov/sra?term=SRX1459690"	"SRA: https://www.ncbi.nlm.nih.gov/sra?term=SRX1462923"	"SRA: https://www.ncbi.nlm.nih.gov/sra?term=SRX1462924"	"SRA: https://www.ncbi.nlm.nih.gov/sra?term=SRX1462925"
!Sample_supplementary_file_1	"ftp://ftp-trace.ncbi.nlm.nih.gov/sra/sra-instant/reads/ByExp/sra/SRX/SRX146/SRX1462311"	"ftp://ftp-trace.ncbi.nlm.nih.gov/sra/sra-instant/reads/ByExp/sra/SRX/SRX146/SRX1462312"	"ftp://ftp-trace.ncbi.nlm.nih.gov/sra/sra-instant/reads/ByExp/sra/SRX/SRX145/SRX1459690"	"ftp://ftp-trace.ncbi.nlm.nih.gov/sra/sra-instant/reads/ByExp/sra/SRX/SRX146/SRX1462923"	"ftp://ftp-trace.ncbi.nlm.nih.gov/sra/sra-instant/reads/ByExp/sra/SRX/SRX146/SRX1462924"	"ftp://ftp-trace.ncbi.nlm.nih.gov/sra/sra-instant/reads/ByExp/sra/SRX/SRX146/SRX1462925"
!series_matrix_table_begin
"ID_REF"	"GSM2054564"	"GSM2054565"	"GSM2054566"	"GSM2054567"	"GSM2054568"	"GSM2054569"
!series_matrix_table_end